齒牙 蝕兒童과 그의 母親의 齒苔에서 分離한 Streptococcus mutans의 血淸型 分布 및 藥劑耐性에 關한 硏究
SEROTYPES AND ANTIBIOTIC SUSCEPTIBILITIES OF STREPTOCOCCUS MUTANS ISOLATED FROM DENTAL PLAQUES OF CHILDREN AND THEIR MOTHERS.
소속 상세정보
김진태(金鎭泰)/Baik Byeong-Ju
백병각(白秉脚)/Kim Jin-Tae
KMID : 0358919840110010075
Abstract
結論
齒牙 蝕症 兒童 82名과 齒牙正常兒 18名 그리고 그들의 어머니 53名을 대상으로 이들의
齒苔로부터 S. mutaons를 분리하여, S. mutans의 分離率, 分離菌洙의 血淸型別 및 抗菌劑에
對한 感受性檢査를 實施한 후 이를 齒牙齬蝕經驗度別, 母子別 및 家族別로 比較하였던바, 그
結果는 다음과 같다.
1. S. mutans의 分離率은 正常兒童에서는 50%였으나 齒牙齬蝕經驗兒童에서는 80.5%로
齒牙 飴經驗兒童에서 菌分 率이 높았으며 이들의 어머니에서는 齒牙 正常人에서는 75%의
檢出率을 보인데 반하여 蝕經驗母에서는 97.5%의 檢出率을 보여 兒童보다는 成人, 齒牙
正常人보다는 蝕經驗者에서 높은 菌檢出率을 보였다.
2. 全 對象人 153名中 單一血淸型은 110名(兒童 ; 68名, 母; 42名)에서, 2種以上의 血淸型
은 14名(兒童, 715, 母 ; 7名)에서 檢出되어 全 分離菌株는 141株(兒童 ; 83株, 母; 58株)였다.
3. 分離株의 血淸型은 c型이 90株(兒童 ; 57株, 母 ; 33株)로 가장 많았고, 다음으로 d型(21
株), e型(15株), f型(9株), g型(4株), a型(1株) 및 非型別株(1株)순이었으며 b型은 單 1株도 檢
出되지 않았다.
4. 分離株의 血淸型의 分布와 蝕經驗度 間에는 關聯性이 없었다.
5. 大部分의 分離菌株가 CM(100%), PC(95.7%), AP(94.3%), GM(92.2%)에는 比較的 높은
感受性을 보였고 CE(73.0%), SM(66.7%) 및 KM(62.4%)에 對해서는 比較的 낮은 感受性을
보여, 全 分離菌株中 91株(64.5%)가 1劑 以上에 대하여 耐性을 보였다.
6. 耐性類型은 20種으로 耐性株의 48.3%가 2劑∼6劑의 多劑耐性株였으며, KM, SM, KM
SM및 CE가 가잔 흔한 耐性型이었다.
7. 母子間의 血淸型의 分布는 本 調査方法으로는 有意한 相關關係를 보이지 않았다.
#초록#
A total of 141 strains of Streptococcus mutans were isolated from dental plaques of
153 subjects. Eighty-two children with caries-experience, 18 caries-free children and
their mothers were participated. All isolates were examined for their serotypes by
immunodiffusion method with 7 reference sera and their antibiotic suscetibilities to 7
antibiotics by agar dilution method using 7 kinds of antibiotics, and were compared their
results by caries experience (DMFT ratio) and by intrafamilial levels.
1. Isolation rate of Streptococcus mutans were greater in samples of carious teeth
than those of sound teeth, and in mothers than in children.
2. Multiple serotypes of Streptococcus mutans were occasionally found in a single
samples.
3. Of the total 141 isolates (83 isolates from children, and 58 from their mothers), type
c isolates were most prevalent(63.8%). Type d,e and f were found, comprizing 14.9%,
10.6% and 6.4% respectively. Serotype g, a and untypable strain were also found but far
lower frequencies (2.8-0.7%), and tope b was detected.
4. These results suggest that there are no significant correlation among the
distribution of serotypes, antibiotic susceptibilities, caries experience and intrafamilial
relationships.
5. Most of isolates were susceptible to chloramphenicol(100%), penicillin(95.7%),
ampicillin(94.3%), and gentamicin(92.2%), but about one-third isolates were resistant to
cephaloridine(27%), streptomycin(33.3%) and kanamycin(47.6%), resulting that 91 strains
(64.5%) among 141 isolates were resistant to one or more drugs used.
6. Of the 91 resistant strains, 20 different resistant patterns were observed, and the
most frequently encountered patterns were KM, SM and CE.
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